ROLE OF HNFA1 GENE VARIANTS IN PANCREATIC BETA CELLS FUNCTION AND GLYCAEMIC CONTROL IN YOUNG INDIVIDUALS WITH TYPE 1 DIABETES

Role of HNFA1 Gene Variants in Pancreatic Beta Cells Function and Glycaemic Control in Young Individuals with Type 1 Diabetes

The HNF1A transcription factor, implicated in the regulation of pancreatic beta cells, as well Chef Pants as in glucose and lipid metabolism, is responsible for type 3 maturity-onset diabetes of the young (MODY3).HNF1A is also involved in increased susceptibility to polygenic forms of diabetes, such as type 2 diabetes (T2D) and gestational diabetes

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The Release of Total Metal Ion and Genotoxicity of Stainless Steel Brackets: Experimental Study Using Micronucleus Assay

BACKGROUND: Stainless steel brackets are composed of various metal that may corrode in oral cavity.Corrosion is caused by the release of metal ions such as chromium, nickel, and iron.The release of metal ions can cause adverse effects such as toxicity, allergic, and mutagenicity.To evaluate the biocompatibility of stainless steel brackets, micronuc

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GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

Abstract Background Loss of the transcription Floor Care Concrete factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cells.Whether and to what extent, GLIS3 regulates thyroid gene transcription in coo

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A physiological increase of insulin in the olfactory bulb decreases detection of a learned aversive odor and abolishes food odor-induced sniffing behavior in rats.

Insulin is involved in multiple regulatory mechanisms, including body weight and food intake, and plays a critical role in metabolic disorders such as obesity and diabetes.An increasing body of evidence indicates that insulin is also involved in the modulation of olfactory function.The olfactory bulb (OB) contains the highest level of insulin and i

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